Endocrine Abstracts

Purpose: To identify predictive biomarkers of recurrence in NFPTs, we used heat shock protein profiling approach to correlate protein expression profiles with tumor recurrence. Heat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in tumors has been implicated in the regulation of apoptosis. In the current study, we attempted to clarify the significance of HSPs in NFPTs and their correlati...

Background: The geographical difference in presentation of primary hyperparathyroidism (PHPT) is well known however, there is spare literature on influence of age and gender on presentation of PHPT.Objective: To study the effect of age and gender on clinical and biochemical presentation of PHPT.Method: This is a retrospective analysis of 184 histopathologically proven PHPT patients between March 1990 and March 2010 from a single ce...

Background: Diabetic striatopathy (DS) is a rare dyskinetic syndrome associated with acute decompensated hyperglycemia that commonly presents as hemichorea-ballism. Its natural history following resolution of the hyperglycemic crisis is not well delineated.Methods: The study was a prospective evaluation of the long-term clinico-radiological outcomes of patients presenting with DS. Neuroimaging (CT/MRI) was performed at baseline and follow-up (>3 mont...

Objective: The primary objective was to characterise the paracrine milieu in three subjects with apparently idiopathic gigantomastia and to study the relative expression of implicated factors in these pathological specimens as compared to tissue samples from normal breast, gynecomastia and breast cancer.Background: Gigantomastia refers to pathological breast enlargement usually occurring in the peripubertal or peripartum period. Idiopathic gigantomastia,...

Introduction: Nelson’s syndrome is a significant long-term complication of bilateral adrenalectomy for Cushing’s disease. However, evidence about possible factors that can predict its occurrence, is controversial and limited.Objective: The objective of this analysis was to elucidate the role of various factors in prediction of Nelson’s syndrome and the extent of their modifying effect.Methods: All patients with Cushi...

Objective: To study O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression to access the efficacy of Temozolamide (TMZ) as a part of multimodality treatment.Background: Aggressive or residual pituitary tumours are associated with substantial morbidity. Treatment options are often limited, and chemotherapy are associated with dismal results. Recent reports have documented the efficacy of TMZ therapy in aggressive pituitary tumors resistant to mult...

Introduction: There is a growing interest in cell-based therapies in T2DM as β-cell failure is progressive and inexorable. This study evaluates the efficacy of autologous bone marrow-derived mesenchymal stem cell transplantation (ABM-MSCT) in T2DM.Methods: This prospective, randomised, single-blinded placebo-controlled study enrolled 20 patients with triple oral hypoglycaemic drug failure and requiring insulin ≥0.4 Units/kg per day for achievi...

Background: Various genetic and environmental factors are appear to contribute to the development of kidney disease in type 2 diabetes. Small ubiquitin-related modifier 4 (SUMO4) appear to play a role in development and/or progression of diabetic nephropathy. Substitution of methionine with valine at codon 55 (M55V) of SUMO4 enhances activity of nuclear factor-kB, a central mediator of inflammation proapoptotic events.Aims: To investigate the association...

Background: According to western literature aerobic Gram-positive cocci are the predominant microorganisms that are isolated from diabetic foot ulcers. In contrast, whatever limited data is available from India Gram-negative aerobic bacteria were most frequently isolated.Aims and objectives: To know the clinical and microbiological profile of patients with infected diabetic foot ulcers.Patients and methods: A descriptive cross-sect...

Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63...